HPV Vaccination, Fibromyalgia and Dysautonomia
Manuel Martínez-Lavín1, Paola-Kinara Reyes-Loyola2 and Laura-Aline Martinez-Martinez3, 1Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico, 2Rheumatology, National Institute of Cardiology, Mexico, Mexico, 3Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, TX, Mexico
Meeting: 2016 ACR/ARHP Annual Meeting
Date of first publication: September 28, 2016
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: In a questionnaire-based case series, we described the clinical features of 45 patients who had the onset of a chronic illness soon after HPV vaccination. Fifty three percent of them fulfilled the 2010 ACR fibromyalgia diagnostic criteria (Clin Rheumatol 2015;34:1981). The objective of the present report is to correlate fibromyalgia severity with dysautonomia severity in an enlarged cohort of patients who developed a chronic ailment soon after HPV vaccination.
Methods: We e-mailed the 2010 ACR fibromyalgia diagnostic criteria questionnaire and a validated dysautonomia questionnaire (COMPASS-31) to individuals who had the onset of a chronic illness after HPV vaccination. Those subjects who had a disease onset within the following three months after HPV immunization are included in this report. We correlate the total COMPASS-31 score with the following 2010 ACR fibromyalgia diagnostic criteria domains: Polysymptomatic Distress Scale, Widespread Pain Index values, and Symptoms Severity Scale.
Results: Fifty five eligible patients filled out both questionnaires. Thirty five (63 %) of them fulfilled the 2010 ACR fibromyalgia diagnostic criteria. At vaccination time, those patients who fulfilled the 2010 ACR fibromyalgia diagnostic criteria were older than those who did not (17 +/- 8 year old vs. 14 +/- 5 year old. P = 0 0.038). Twenty three percent of all post HPV vaccine fibromyalgia girls had their disease onset within 24 hours after vaccination.
In the fibromyalgia group COMPASS-31 score was 52-4 +/- 17-8, reflecting widespread dysautonomia symptoms. Likewise fibromyalgia domain scores were high, implying the presence of severe fibromyalgia (table). COMPASS-31 score correlated with the three 2010 fibromyalgia diagnostic criteria domains: With Polysymptomatic Distress Scale (rho=0.642, p<0.0001), with Widespread Pain Index (rho=0.550, p=0.001) and with Symptoms Severity Scale (rho=0.633, p<0.0001). After a mean period of 4.5 years after vaccination, none of the immunized girls with fibromyalgia was able to work or attend school on a regular basis.
Conclusion: This questionnaire-based case series sub-analysis suggests that in young girls, disabling fibromyalgia may follow HPV vaccination. Correlations between Compass-31 scores and the 2010 fibromyalgia diagnostic criteria questionnaire suggest that in this group of HPV vaccinated girls, fibromyalgia and dysautonomia may share clinical and pathogenetic features.
|Post HPV vaccination fibromyalgia patients (n = 35)|
|Age (years)||20 ± 8|
|Age at first HPV dose||17 ± 8|
|Illness onset within 24 hr. after vaccination, n (%)||8 (22.9%)|
|Illness onset between 24 hours to 3 months, n (%)||27 (77.1%)|
|ACR 2010 FM Polysymptomatic Distress Scale||36 ± 13|
|ACR 2010 FM Widespread Pain Index||10 ± 5|
|ACR 2010 FM Symptoms Severity Scale||26 ± 9|
|COMPASS-31 scale value||52.4 ± 17.8|
Disclosure:M. Martínez-Lavín, None; P. K. Reyes-Loyola, None; L. A. Martinez-Martinez, None.
To cite this abstract in AMA style:Martínez-Lavín M, Reyes-Loyola PK, Martinez-Martinez LA. Human Papilloma Virus Vaccination, Fibromyalgia and Dysautonomia [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/human-papilloma-virus-vaccination-fibromyalgia-and-dysautonomia/. Accessed January 4, 2020.
This article is from 2016 – but it’s still as relevant as many other articles that get suppressed by Google and the vaccine industry.
You may ask, how does the vaccine industry suppress research that shows that vaccines are causing very severe side effects?
It’s very easy. If you have enough people working for you, you just let them write, quote and link articles about how great vaccines are. After a short amount of time the “negative” articles will only show up on Google if you search through many pages of search results. So nobody is reading those articles anymore and this will even multiply the effect.